PPI Use in 1st Trimester

PPI Use in 1st Trimester

Postby PharmD » Tue Dec 14, 2010 4:40 pm

Pasternak B, et al. from Statens Serum Institut in Copenhagen, Denmark conducted a cohort study = association between exposure to PPIs during pregnancy and the risk of major birth defects among all infants born alive in Denmark between (January 1996-September 2008) showed proton-pump inhibitors (PPIs) use during the month before conception = associated with sign. inc. risk for major birth defects.

European surveillance of congenital anomalies (EUROCAT) [standardized classification scheme] = used to categorize major birth defects (within the 1st year of life). PPI use b/tw 4 weeks before conception -> end of the first trimester = 5,082/840,968 live births. (174 (3.4%) had major birth defects). PPI use only during the 1st trimester = 118/3651 (3.2%) had major birth defects [adjusted prevalence OR, 1.10; 95% CI, 0.91-1.34] = no significant association.

Gastroesophageal reflux common esp. in pregnant women in the first trimester. PPIs = most efficacious treatment; omeprazole class C pregnancy, other PPIs class B.

PPI use in 1st trimester of pregnancy = not associated with an increased risk for major birth defects; no significant association - any specific PPIs with the risk for birth defects + no increased risk any other bodily system.
N Engl J Med. 2010; 363:2114-2123, 2161-2163.
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